It is apparent that Cx43 plays a pivotal role in the epidermis, as highlighted by a fatal defect in barrier function in genetically-modified mice harboring a C-terminal truncated mutant of Cx43 [49] and the association between some Cx43 mutations and skin disorders [17,18,20,21,22,50,51,52,53,54,55,56]. Here, GJA1 is linked to skin disorder.