HUWE1 and hepatocellular carcinoma: Mechanisms of HCC inhibition by GNMT include: the suppression of dep domain-containing mTOR-interacting protein (DEPTOR) to the activation of mTOR targets SK6 and 4E-BP, that further impedes PI3K/AKT signaling pathway, the repression of the proteasomal degradation of phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 (PREX2) by the E3 ubiquitin ligase HectH9, the maintenance of adequate proteins levels that related in the anti-oxidation and detoxification response and 1C metabolism pathways that could impede HCC development [28].