SERPINE1 and osteoporosis: Our findings also suggested that the effects of glucocorticoids on osteoporosis were due to elevated serum PAI-1 levels secreted from adipose tissues, but not local PAI-1 production by bone tissues in mice; however, hepatic tissue appeared to be more important as the secretory organ for circulating PAI-1 in type 1 diabetic bone loss in female mice [21,37].