Experiments on components of the Hippo pathway (combined overexpression of Mst1 (Macrophage Stimulating 1) and knock-down of Yap (Yes-Associated Protein 1)) resulted in the suppression of cancer cell migration and proliferation, activation of caspase-9-related apoptosis, respiratory function, ATP production, and mitochondrial membrane potential. The gene discussed is YAP1; the disease is cancer.