SLC5A5 and neoplasm: In addition, alteration in the expression of genes responsible for iodine transport and metabolism (such as NIS (Sodium/Iodide Symporter) or SLC5A5 (Solute Carrier Family 5 Member 5)) are frequent, so the tumours could not accumulate iodine and respond to radioactive iodine therapy, which resulted in negative prognosis [12].