CWC22 and retinal degeneration: The most upregulated gene in the neuroretina of Gnat1rd17 mice, Cwc20, was a CWC22 spliceosome-associated protein (Figure 3b) that functions as the major partner of CWC27 (CWC27 spliceosome-associated cyclophilin), a splicing factor linked to retinal degeneration and other developmental defects [45,46].