The signaling by L1 in CRC cells involves an L1-ezrin-NF-κB pathway [5,6] and results in the activation of numerous genes that contribute to the tumorigenic properties conferred by L1 overexpression [6,7,8,9,10,11,12,13,14], including several genes defined as colonic stem cell signature genes [6,8,10,11]. The gene discussed is NFKB1; the disease is colorectal carcinoma.