The results summarized in Figure 4A demonstrate that when NF-κB signaling was blocked in CRC cells by suppressing the expression of the p65 subunit of NF-κB, using an shRNA to p65, or the IκB super repressor (IκB-SR), the ability of L1 to induce biglycan in L1-expressing CRC cell clones was blocked (Figure 4A). Here, BGN is linked to colorectal carcinoma.