Anti-integrin αvβ3 antibodies, but not anti-integrin αvβ5 antibodies, were demonstrated to abrogate the T4-induced PCNA accumulation in both NCI-H522 cells and NCI-H510A cells, indicating integrin αvβ3 as mediator of T4-induced PCNA accumulation in lung cancer cells. The gene discussed is PCNA; the disease is lung carcinoma.