Excitingly, treatment of Fbn1C1039G/+ mice with nicotinamide riboside, a NAD+ precursor that enhances mitochondrial metabolism by increasing Pgc1a and Tfam expression, was able to revert the development of aortic aneurysm and to restore histological features of medial degeneration. The gene discussed is TFAM; the disease is aortic aneurysm.