Distribution of LAP3, DNAJB11, MANF and EIF3K was mainly present in the lining of OA and CPPA with low histological inflammatory score (Figure 4: OA with HIS = 4 and CPPA with HIS = 5), whereas it was strongly present in the stroma of OA, CPPA and RA biopsies with high histological inflammatory score (Figure 4: OA, CPPA and RA with HIS = 7, HIS = 9 and HIS = 17, respectively). The gene discussed is MANF; the disease is rheumatoid arthritis.