In this study, having discovered that ADAM12 upregulation and miR-29a downregulation is also impaired in ischemic GA muscle of mice with DM2 (Figure 1A,B), we then hypothesized that the overexpression of ADAM12 or inhibiting its regulatory miR-29a will improve perfusion recovery and skeletal muscle function in experimental PAD. The gene discussed is ADAM12; the disease is peripheral arterial disease.