SERPINE1 and pulmonary arterial hypertension: Currently, cell senescence is considered an important player in diseases such as COVID-19 where the senescence landscape is present [29,30]; idiopathic pulmonary fibrosis (IPF) for which has been observed an increase in factors such as β-galactosidase, p21, p16, p53 and high levels of plasminogen activator inhibitor 1 (PAI-1) associated with alveolar type 2 cells [31,32,33]; chronic obstructive pulmonary disease (COPD) that links to mTOR activation to favor the development of lung emphysema, pulmonary hypertension, and inflammation [34].