Hypermethylation in the potassium voltage-gated channel, Isk-related family, member 3 (KCNE3), TSPY-like 5 (TSPYL5), Homeobox A11 (HOXA11), HOXA11 antisense RNA (HOXA11AS), HOX9, and LOC100130872, was observed in leiomyosarcoma [75]. The gene discussed is TSPYL5; the disease is leiomyosarcoma.