HDAC4 is upregulated in leiomyosarcoma, and LMK235, a specific HDAC4 inhibitor, dose-dependently suppressed MKK7 transcription and JNK/c-Jun activity in early brain injury following subarachnoid hemorrhage and impaired neuronal apoptosis [117]. The gene discussed is MAP2K7; the disease is leiomyosarcoma.