Many genetic mutations have been reported in dedifferentiated liposarcomas, including mutations in MDM2, CDK4, high mobility group AT-hook 2 (HMGA2), fibroblast growth factor receptor substrate 2 (FRS2), and neuron navigator 3 (NAV3), all located in 12q13-15 [93] (Figure 3). This evidence concerns the gene FRS2 and liposarcoma.