It catalyzes the reversible phosphotransferase reaction from 1,3-bisphosphoglycerate (1,3-BPG) to MgADP, to generate 3-phosphoglycerate (3-PG) and the first ATP in the glycolysis pathway [21], by doing so it plays a vital role in cell energy metabolism, that motivated us to suppose Pgk1 centers in the pathogenesis of the gastrointestinal disease. This evidence concerns the gene PGK1 and gastrointestinal disease.