The B cell phenotypes of the PBMC from T1D patients carrying the C1858T PTPN22 variant after treatment of targeted and untargeted lipoplexes at 80 and 100 pmols of siRNA were analyzed after 4 days of CpG oligodeoxynucleotides stimulus (Figure 10). The gene discussed is PTPN22; the disease is type 1 diabetes mellitus.