CAR was further generated that target overexpressed antigens in breast cancer, lung cancer, and pancreatic cancer, such as carcinoembryonic antigen GD2, prostate-specific membrane antigen, HER2/ERBB2, MUC16 [49] or tumor stroma (fibroblast activation protein or vascular endothelial growth factor receptor, VEGFR) [50]. The gene discussed is ERBB2; the disease is breast cancer.