Echocardiography of the heart showed a clear increase in end-diastolic diameter (EDD) and end-systolic diameter (ESD) in control ApoE−/−Fbn1C1039G+/− mice at week 17 and 25 of WD, which was normalised to the level of ApoE−/− mice after ASA treatment (Figure 4C,D). Here, APOE is linked to Wilson disease.