This perspective is supported by the modest correlation observed between LGR5 and CEA expression in lymph nodes (r = 0.28) and the results of the two-color immunofluorescence staining in the primary tumor tissues, where CEA and EpCAM colocalize only at the epithelium’s luminal surface, while LGR5 colocalizes with EpCAM all over the epithelial cells, suggesting the main expression of CEA in highly differentiated tumor cells, following earlier studies [28]. Here, CEACAM5 is linked to neoplasm.