CD274 overexpression is a statistically significant poor prognostic factor in multiple solid tumors (OS (HR = 1.58, 95% CI = 1.38–1.81, p < 0.000) and DFS/PFS (HR = 1.72, 95% CI = 1.26–2.33, p = 0.001)); overall survival analysis previously showed a statistically significant detrimental effect of PD-L1 in GC (HR = 1.56, 95% CI = 1.02–2.37, p = 0.040) [18]. This evidence concerns the gene CD274 and gastric cancer.