Moreover, prostate cancer-associated non-coding RNA1 (PRNCR1, a lncRNA) and prostate cancer gene expression marker 1 (PCGEM1, a lncRNA) were highly expressed in CRPC cells and reported to be involved in AR signaling pathway, while knockdown of either PRNCR1 or PCGEM1 would suppress in vivo tumor growth of CRPC [44,45,46]. Here, AR is linked to Familial prostate cancer.