MYCN and neuroblastoma: Initially, we evaluated the dose-dependent potency of DpC to induce cell death in various neuroblastoma cell lines and found that 20 μM DpC induces a similar response in both the MYCN-nonamplified cell line SH-SY5Y and the MYCN-amplified cell line SK-N-BE(2), killing half of the cells within 24 h (Figures S1 and S2).