Consequently, atorvastatin treatment increased TβRII expression in the atheroma plaque in an experimental model of atherosclerosis in Apolipoprotein E Knockout mice, which was associated to beneficial effects, including amelioration of disease progression and stabilization of the atheroma plaque by increased CCN2 expression and collagen content [58]. The gene discussed is TGFBR2; the disease is atherosclerosis.