Moreover, caspase-1 is involved in the pathogenesis of several diseases, including periodontal disease [4], Alzheimer’s disease [81,82], cardiovascular disease [83], rheumatoid arthritis [84], endometriosis [70], and Crohn’s disease [85], all of which are characterised by cell death and inflammation. The gene discussed is CASP1; the disease is early-onset autosomal dominant Alzheimer disease.