DUSP1 and osteoarthritis: In addition, DUSP-1 expression in the synovium of patients with osteoarthritis was found to be lower than that in the synovium of normal subjects (GEO accession number GDS5401 and GDS5403) [41], and the incidence and severity of arthritis was significantly higher in DUSP-1-deficient mice than in wild-type mice [42].