IL1B and Low back pain: The proinflammatory cytokines interleukin (IL)-1β, IL-6, and tumor necrosis factor α are considered to be involved in LBP development, because they can induce a number of catabolic proteinases that cause IVD degeneration, as well as produce pain-associated molecules, including prostaglandin (PG) E2 and NGF in IVD cells [20,21,22,23].