CD274 and cancer: In addition, the expression levels of miR-675-5p differ in different cancers contributing to several functions such as cell proliferation and invasion, as well as metastasis [47,48]; the downregulation of miR-675-5 by p38 MAPK activation provides stability to the PD-L1 RNA through the 3’-UTR region and thus causes PD-L1 accumulation.