Recently, it has been shown that the activation of endothelial p38 by IL-1β regulates miR-31 transcription through the activation of c-fos and GATA2 and, in turn, miR-31 inhibits E-selectin expression repressing the trans-endothelial adhesion phenomenon and the migration of colon cancer cells [58]. This evidence concerns the gene MAPK1 and malignant colon neoplasm.