In the Eμ-TCL1 murine model of CLL, it was indicated that the stroma cells from the leukemia microenvironment overexpressed genes related to the chemotaxis of neutrophils, including chemotactic factors (S100A8, S100A9), receptors (CXCR2), inflammatory cytokines (IL-1beta), and integrins (Itgam/CD11b) [40]. The gene discussed is IL1B; the disease is B-cell chronic lymphocytic leukemia.