Our group recently showed that the leucine-rich domain (LRD, aa1558–1951, isoform 2) of neurofibromin, which consists of the Sec14-pleckstrin homology (PH) domain (aa 1558–1817) and part of the Heat-like repeat (HLR; aa1818–1951), inhibits NF1-loss induced cell invasion in human glioma stem cells (GSC) and orthotopic mouse glioma model independent of RAS [122] (Figure 7). This evidence concerns the gene PLEK and central nervous system cancer.