Furthermore, SLAB51 chronic administration counteracted the increase of nitrite plasma concentration and iNOS cerebral levels, indicating both an antioxidant and anti-inflammatory effect of SLAB51, in agreement with previously published data on the increased gut concentration of anti-inflammatory bacterial metabolites in 3xTg-AD mice treated with the same probiotic formulation [5] and with the ameliorated oxidative status in this animal model [6]. This evidence concerns the gene NOS2 and Alzheimer disease.