The present study aimed to evaluate the ability of SLAB51 oral treatment to induce HIF-1α stabilization, also analyzing the effect on PHD2 expression, along with inhibition of inducible nitric oxide synthase (iNOS) expression and activity in the brain of a well-known AD animal model (3xTg-AD mice), thus supporting the neuroprotective effects of probiotics oral supplementation on neuroinflammation in AD. This evidence concerns the gene NOS2 and Alzheimer disease.