REN and hypertensive disorder: The most common complications in SAS patients are hypertension and diabetes, and IH (caused by SAS) decreases miR-203 in hepatocytes [5] and juxtaglomerular cells [77], resulting in increased selenoprotein P in hepatocytes (a diabetogenic hepatokine) and renin in juxtaglomerular cells (which induces hypertension) simultaneously.