Regarding the significance of GATA factors in IH condition, Park et al. reported the involvement of Gata4 in the IH-induced up-regulation of B cell lymphoma 2 (Bcl-2) and B cell lymphoma-extra large (Bcl-xL) in mouse myocardial cells, although the mechanism by which IH activates Gata4 to induce Bcl-2 and Bcl-xL has been elusive [105]. This evidence concerns the gene BCL2L1 and isolated hemihyperplasia.