SELENOP and Insulin resistance: In human hepatocytes, Uchiyama et al. demonstrated that IH stress up-regulates the levels of SELENOP, which encodes selenoprotein P, a causative factor of insulin resistance, and up-regulates the levels of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) mRNAs to proliferate the hepatocytes, via the microRNA (miR)-203 mediated mechanism, resulting in the proliferation of liver cells with high levels of SELENOP mRNA [5].