FOXO1 and Glucose intolerance: However, SIRT6 regulates glucose sensing in pancreatic β cells, and by suppressing SIRT6, in pancreatic β-cells, forkhead box protein O1 (FOXO1) is deacetylated and pancreatic and duodenal homeobox 1 (PDX1) and GLUT2 expression is diminished inducing systemic glucose intolerance [113].