MGPTs generally cover at least 10 common HR-related genes such as ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, NBS1 (NBN), PALB2, RAD51C, and RAD51D, all of whose germline alterations are associated with BRCAness phenotypes for predisposition to breast, ovarian, prostate, or pancreatic cancer. This evidence concerns the gene PALB2 and familial pancreatic carcinoma.