MGPTs generally cover at least 10 common HR-related genes such as ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, NBS1 (NBN), PALB2, RAD51C, and RAD51D, all of whose germline alterations are associated with BRCAness phenotypes for predisposition to breast, ovarian, prostate, or pancreatic cancer. The gene discussed is CHEK2; the disease is pancreatic neoplasm.