Breast cancer risk in females with GVPs of BRIP1 is stated as “potential”, with insufficient evidence for risk management whereas there are increased risks for ovarian cancer, justifying the consideration of risk-reducing salpingo-oophorectomy (RRSO) at around 45–50 years of age (with a discussion) or earlier, based on specific family history of an earlier onset of ovarian cancer (NCCN Guidelines® Version 1.2022, www.nccn.org, accessed on 19 November 2021). This evidence concerns the gene BRIP1 and ovarian cancer.