The estimated frequencies of developing malignancies are 0.1% for prostate cancer and 0.5% for pancreatic cancer, while the relative risks for their lifetime incidence were reported to increase significantly (up to 20-fold for prostate cancer and 10-fold for pancreatic cancer) upon association with BRCA2 [28,86]. The gene discussed is BRCA2; the disease is familial pancreatic carcinoma.