MAPT and Alzheimer disease: Some studies have shown that the pathological biomarkers of AD mainly include extracellular deposition of senile plaques (SPs) composed of amyloid-β protein (Aβ) and intracellular accumulation of neurofibrillary tangles (NFTs) consisting of hyperphosphorylated Tau (p-Tau), as well as neuronal loss in different brain regions.