Furthermore, under normal conditions, Tau is preferentially degraded by the macroautophagy pathway [14,85]; however, a majority of Tau is found in the form of hyperphosphorylation in the axonal of AD models [66], which shows it is not only dysfunctional, but also pathogenic as it can induce microtubule malformations, disrupt the microtubule-mediated transport, further impair the fusion of autophagosome and lysosome [66], while leading to the accumulation of AVs [78]. The gene discussed is MAPT; the disease is Alzheimer disease.