In this study, we demonstrate that Pectin and Tributyrin diets mitigate infectious colitis through a multitude of events, including recruitment of the stem cell markers Lgr4, Lgr5, and Lgr6 to promote crypt regeneration, partial reversal of bacterial dysbiosis, increased expression of MUC2, DCLK1, NOD2, SIGIRR (single immunoglobulin IL-1R-related molecule), and several other anti-inflammatory genes. The gene discussed is SIGIRR; the disease is infectious colitis.