The molecular mechanisms by which STIM1-dependent SOCE regulates cervical cancer cell migration mainly are through the Ca2+-dependent molecules controlling the focal adhesion turnover and actomyosin contractility, including calpain protease, myosin light chain kinase (MLCK), and focal adhesion proteins protein-rich tyrosine kinase (Pyk2), focal adhesion kinase (FAK), and talin. This evidence concerns the gene STIM1 and cervical cancer.