PPARG and Insulin resistance: Induction of PPARγ knockout at the late stages of adipogenesis, several inconsistencies between fat mass and insulin resistance in different organs, and the timing of the appearance of lipodystrophy in PPARγ phenotypes (a few days in one study [72] and several months in another [73]), as well as the striking phenotype of Adipo-Cre PPARγ −/− mice [76], due to the pleiotropic function of PPARγ, prompted researchers to generate a new transgenic model with inducible PPARγ knockout.