PPARG and Insulin resistance: For instance, in the study of He et al. under HFD conditions, fat-specific PPARγ knockout mice were found to be hyperinsulinemic and to display insulin resistance (IR) in fat and liver, but not in muscle [73], while in another study by Jones et al., PPARγ-selective knockout under HFD challenge leads to muscle insulin resistance but an overall improvement in insulin sensitivity due to the increased glucose uptake in the liver [75].