Noticeably, two other genes, PPARGC1A and PER3, not reported in the MS-GWAS catalog and involved in the circadian clock, both functional partners of NR1D1, were found differentially expressed in MS vs. control jugular wall and, in families with disturbed brain blood outflow, harbored SNPs with intriguing links to vascular aspect in MS. This evidence concerns the gene PER3 and myeloid sarcoma.