On the other hand, Rorive et al. [82] evaluated the role of the exogenously added recombinant galectin-1 on cell kinetics of U87, U373, and H4 glioma cell lines, and found no significant effects either on mitosis, cell cycle progression, or growth rate, hinting at a possible intracellular mechanism that could underlie the effects of galectin-1 on glioma cell growth. This evidence concerns the gene LGALS1 and central nervous system cancer.