Interestingly, galectin-1 knocked-down U87 cells showed increased expression of pro-proliferative factors such as proliferating cell nuclear antigen (PCNA) and cyclin D3, as well as antiproliferative factors such as p53 and p21, suggesting mixed effects of galectin-1 on glioma cell cycle progression [81]. This evidence concerns the gene LGALS1 and glioma.