We examined RNA expression of the major components of elastic fibers, including tropoelastin (Eln), fibrillin-1(Fbn1), lysyloxidase (Lox), fibulin-5 (Fbln5), and fibulin-4 (Fbln4), using quantitative real-time PCR (qPCR), to investigate the synthesizing ability of elastic fiber components in the aortic tissue of Hspg2−/−-Tg mice without AD. The gene discussed is FBN1; the disease is Alzheimer disease.