The observed permeability of the blood–brain barrier was still present 1 year after ischemia and was associated with the development of diffuse amyloid plaques, modified tau protein and progressive death of pyramidal neurons, and an increased number of activated neuroglial cells in areas of the hippocampus that are sensitive and insensitive to ischemia (Figure 1) [4,5,6,7,46,48,49,139,140]. The gene discussed is MAPT; the disease is ischemia.