IL1B and injury: Melatonin stimulated the production of IL-2 and IL-1β, which stimulated cell immunity [161], and melatonin administration after trauma-hemorrhage was shown to significantly improve depressed immune functions, which was confirmed by the restoration of peritoneal macrophage IL-1 and IL-6 release, as well as significantly improve splenocyte IL-2 and IL-3 release and splenocyte proliferative capacity [179].