Jin et al. [80] demonstrated the importance of netrin-1 in tumor development under hypoxia, which is a microenvironment condition of non-small cell lung cancer by the detection of an epithelial-to-mesenchymal transition, which is mediated by netrin-1 through the phosphoinositide 3 kinase/AKT pathway. Here, NTN1 is linked to non-small cell lung carcinoma.