We were able to show that lipid lowering in established atherosclerosis and silencing macrophage-specific netrin-1 by a tamoxifen-inducible knock-out reduced the infiltration of intimal smooth muscle cells, macrophage accumulation, and survival in plaques, while markers of inflammation such as IL-10 and efferocytosis were simultaneously increased [100]. Here, NTN1 is linked to atherosclerosis.