MLC1 and brain inflammatory disease: Interestingly, in different cellular models (human astrocytoma cells and MLC1 KO primary astrocytes) MLC1-inhibits specific intracellular signaling cascades responsible for astrocyte activation and proliferation following brain inflammation/stress (pEGFR/pERK/pNF-kB/PLCγ/pSTAT3), [107,111,112].