Indeed, increased NOS activity is a feature of many tumors, e.g., lung, colon, and head and neck carcinomas [32,33,34,35,36,37] In Chinese hamster ovary (CHO)-K1 cells, treatment with basic fibroblast growth factor (bFGF) induced eNOS-mediated NO generation, which contributed to cell proliferation through the cGMP/PKG axis and ceramide synthesis [38]. Here, FGF2 is linked to head and neck carcinoma.