Among the latest molecules, the lactam-derived and orally bioavailable EZH2 antagonist PF-06821497 [201] and SHR2554 are potent and orally available EZH2 antagonists, being evaluated in open-label, multi center, phase 1 dose-escalation trials with R/R FL and DLBCL patients (NCT03460977) and R/R mature lymphoid neoplasms (NCT03603951), respectively. This evidence concerns the gene EZH2 and lymphoid neoplasm.