When NSCLC cells were treated with the LSD1 inhibitor sp2509, both H3K4me2 and RpolII were enriched at the E-cadherin promoter, as expected, suggesting that TdIF1 acts by recruiting LSD1, which in accordance with our observation that RpolII was enriched after treatment with siTdIF1 (Figure 4D). The gene discussed is CDH1; the disease is non-small cell lung carcinoma.