Regarding optimizing MSCs with prior treatment protocols, Guo J et al., 2008, reported that pretreatment of MSCs with IGF-1 enhanced engraftment in the infarct-border zones, increased capillary density, and attenuated cardiac dysfunction, left ventricular chamber enlargement, and scar formation in a rat model of myocardial infarction [35]. Here, IGF1 is linked to myocardial infarction.