Interestingly, BACE1 and nicastrin (components of γ-secretase) levels increased in HSV-1 infected human neuroblastoma SHSY5Y cells [163]; HSV-1 can also elevate IFN-induced PKR level, leading to the expression of BACE1, which is otherwise constitutively inhibited [189]. The gene discussed is BACE1; the disease is neuroblastoma.