Incomplete remyelination can be caused by the transition to a reactive state, as well as by the death of the glial cells responsible for this process, such as astrocytes and microglia [94], and contribute to clinical manifestation in the form of cognitive decline, as myelin impairment can play a significant role in AD pathology and precede Aβ and tau pathologies during the disease [95]. Here, MAPT is linked to Alzheimer disease.