HSV-1 DNA is sensed by TLR9, interferon γ (IFN-γ)-inducible protein 16 (IFI16), DNA-dependent activator of IFN-regulatory factors (DAI), and cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) (Figure 1) (it is speculated whether cGAS recognizes HSV-1 DNA or the host’s mitochondrial DNA released following infection [34]), as reviewed by Danastas et al. and Zhao et al. [35,36]. This evidence concerns the gene ZBP1 and infection.