STK11 and non-small cell lung carcinoma: Consistent with these basic molecular analyses, a pan-cancer T-cell-inflamed gene expression profile (GEP) consisting of 18 genes, which represent the T-cell-activated tumor microenvironment (TME), revealed that somatic mutation of LKB1 was one of the most prevalent driver alterations in immunosuppressed phenotypes in NSCLC known as “cold tumor” [19].