Somatic mutation of LKB1 occurs in approximately 20% of lung adenocarcinomas and 30% of KRAS-mutant lung adenocarcinomas, whereas LKB1 inactivation is present as a germline mutation of the autosomal dominant disorder, Peutz–Jeghers syndrome [23,24,57]. The gene discussed is KRAS; the disease is lung adenocarcinoma.