This molecular mechanism is consistent with the invariable stabilization of aberrant PD-L1 transcripts by structural variations, which disrupt the 3′-region of the PD-L1 gene through 3′-UTR truncation in multiple cancer types, such as adult T-cell leukemia/lymphoma and diffuse large B-cell lymphoma [54]. Here, CD274 is linked to diffuse large B-cell lymphoma.