The involvement of P2X7R-mediated NLRP3 inflammasome activation in IL-1β production in mouse macrophages supplemented with human hepatic stellate cells might contribute to extracellular matrix deposition and suggests that blockade of the P2X7R-NLRP3 inflammasome axis represents a potential therapeutic target for liver fibrosis [109,110]. The gene discussed is NLRP3; the disease is Hepatic fibrosis.