The crucial role of melatonin in the development of NAFLD, probably via mitogen-activated protein kinase (MAPK)/c-Jun N-terminal kinase (JNK) signaling [97] or elevating activation of apoptosis signal-regulating kinase 1 (ASK1) and downstream signaling pathways to decrease de novo lipogenesis in the liver [98], and via the nuclear receptor subfamily, 4 group A member 1 (NR4A1)/DNA-PKs/p53 pathway [99]. This evidence concerns the gene MAP3K5 and metabolic dysfunction-associated steatotic liver disease.