NDUFB6 and Leber hereditary optic neuropathy: More recently, a new genetic landscape has emerged for LHON as clinical phenocopies indistinguishable from the mtDNA-related disease are being identified as recessive traits associated with nuclear-encoded components of cI or incompletely penetrant mildly pathogenic variants in OXPHOS-related gene products, such as the Tyr51Cys of DNAJC30 gene [75,76].